Chylomicron metabolism in rats: kinetic modeling indicates that the particles remain at endothelial sites for minutes
نویسندگان
چکیده
منابع مشابه
Chylomicron metabolism.
Chylomicrons are the 'orphans' of the lipoprotein family. Difficulty of measurement has impeded understanding of their metabolism. Plasma concentrations of chylomicrons and chylomicron remnants give no insight into the magnitude of substrate flux through these pathways. A defect in clearance of chylomicron remnants is probably an indication of a more generalized defect in lipoprotein metabolism...
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It has been amply demonstrated that the chylomicron is a particulate complex of triglyceride, cholcstcrol c&r, phospholipide, and protein (l-4) and is the form in which most of the exogenous triglyceride (5) and choltstcrol (6, 7) is transported from the intestinal tract to the tissuts via the lymph and blood. Although the m&holism of the triglyccridc moiety of the chylomicrons has been studied...
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15 صفحه اولKinetic modeling predicts a stimulatory role for ribosome collisions at elongation stall sites in bacteria
Ribosome stalling on mRNAs can decrease protein expression. To decipher ribosome kinetics at stall sites, we induced ribosome stalling at specific codons by starving the bacterium Escherichia coli for the cognate amino acid. We measured protein synthesis rates from a reporter library of over 100 variants that encoded systematic perturbations of translation initiation rate, the number of stall s...
متن کاملChylomicron-remnant-like particles modify production of vasoactive mediators by endothelial cells.
Endothelial-cell dysfunction is a critical initiating event in the pathogenesis of atherosclerosis. Although there is evidence to suggest that chylomicron remnants (CMRs), lipoproteins derived from the diet, influence endothelial-cell function to generate a pro-atherogenic phenotype, the mechanisms involved remain undefined. We have examined the effects of CMR-like particles (CMR-LPs) on human ...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2013
ISSN: 0022-2275
DOI: 10.1194/jlr.m032979